Title: Professor, Geriatric Medicine, University of Colorado Denver - Anschutz Medical Campus

Contact: kerrie.moreau@cuanschutz.edu

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Personal Statement
I have been conducting clinical research studies focusing on sex hormones, exercise and cardiovascular aging for 20 years. My laboratory investigates the mechanisms underlying vascular protection of gonadal hormones, including how declines in ovarian function during the menopause transition, and low testosterone in aging men, contributes to an acceleration in cardiovascular aging, as characterized by endothelial dysfunction, arterial stiffening. intimal-medial thickening and cardiac dysfunction. As an exercise physiologist, we also investigate the modulatory influence of sex hormones on cardiovascular adaptations to habitual exercise. My laboratory uses a variety of experimental techniques and skills to study the integrative biology of the aging vasculature in humans, which has allowed me to develop a successful clinical research program to study the mechanisms underlying sex hormone deficiency and vascular aging in humans.

Research Interest
My translational research approach includes ultrasound imaging to examine the arteries and heart, gonadal suppression interventions to isolate the role of sex hormones, infusion models to isolate the influence of oxidative stress, and endothelial cell harvests from peripheral veins and arteries to determine cellular mechanisms. I am currently the PI on an NIH R01 award investigating the cardiovascular consequences of low testosterone in older men and its contributions to Alzheimer’s Disease risk and its related dementias in middle-aged and older men. Additionally, I am the Director of the Cardiovascular BioImaging Core at the University of Colorado Denver Anschutz Medical Campus which is a dedicated research facility for protocols utilizing cardiovascular imaging. In summary, I have demonstrated a productive record in carrying out clinical research studies that impact public health.

Recent Publications

The following research fields have been used to summarize Dr. Moreau's publication (the number in parentheis is the times that research field has appeared). The categories are based on 101 publications with 2,467 citations of her work, 65% of her publications have at least 1 citation:

• Clinical Research (62)
• Aging (54)
• Cardiovascular (49)
• Prevention (36)
• Contraception/Reproduction (33)
• Estrogen (31)
• Heart Disease (22)
• Clinical Trials and Supportive Activities (15)
• Nutrition (13)
• Lung (9)
• Chronic Obstructive Pulmonary Disease (8)

2022

Erickson ML, Allen JM, Beavers DP, Collins LM, Davidson KW, Erickson KI, Esser KA, Hesselink MKC, Moreau KL, Laber EB, Peterson CA, Peterson CM, Reusch JE, Thyfault JP, Youngstedt SD, Zierath JR, Goodpaster BH, LeBrasseur NK, Buford TW, Sparks LM. Understanding heterogeneity of responses to, and optimizing clinical efficacy of, exercise training in older adults: NIH NIA Workshop summary. Geroscience. 2022 Oct 15. doi: 10.1007/s11357-022-00668-3. Epub ahead of print. PMID: 36242693

DuBose LE, Ozemek C, Wick T, Richardson V, Hildreth KL, Moreau KL. Role of BH4 Deficiency as a Mediator of Oxidative Stress-Related Endothelial Dysfunction in Menopausal Women. Am J Physiol Heart Circ Physiol. 2022 Sep 23. doi: 10.1152/ajpheart.00435.2022. Epub ahead of print.
PMID: 36149770

Kuczmarski AV, Welti LM, Moreau KL, Wenner MM. ET-1 as a Sex-Specific Mechanism Impacting Age-Related Changes in Vascular Function. Front Aging. 2021 Aug 31;2:727416. doi: 10.3389/fragi.2021.727416. PMCID: PMC9261354. PMID: 35822003
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Babcock MC, DuBose LE, Hildreth KL, Stauffer BL, Cornwell WK 3rd, Kohrt WM, Moreau KL. Age-associated reductions in cardiovagal baroreflex sensitivity are exaggerated in middle-aged and older men with low testosterone. J Appl Physiol (1985). 2022 Jun 30. doi: 10.1152/japplphysiol.00245.2022. Epub ahead of print.
PMID: 35771224
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Pabon M, Cheng S, Altin SE, Sethi SS, Nelson MD, Moreau KL, Hamburg N, Hess CN. Sex Differences in Peripheral Artery Disease. Circ Res. 2022 Feb 18;130(4):496-511. doi: 10.1161/CIRCRESAHA.121.320702. Epub 2022 Feb 17.
PMID: 35175843.
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2021

Marlatt KL, Pitynski-Miller DR, Gavin KM, Moreau KL, Melanson EL, Santoro N, Kohrt WM. Body composition and cardiometabolic health across the menopause transition. Obesity (Silver Spring). 2022 Jan;30(1):14-27. doi: 10.1002/oby.23289.
PMID: 34932890.
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Babcock MC, DuBose LE, Witten TL, Stauffer BL, Hildreth KL, Schwartz RS, Kohrt WM, Moreau KL. Oxidative stress and inflammation are associated with age-related endothelial dysfunction in men with low testosterone. J Clin Endocrinol Metab. 2021 Oct 1:dgab715. doi: 10.1210/clinem/dgab715. Epub ahead of print.
PMID: 34597384

Streed CG Jr, Beach LB, Caceres BA, Dowshen NL, Moreau KL, Mukherjee M, Poteat T, Radix A, Reisner SL, Singh V; American Heart Association Council on Peripheral Vascular Disease; Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Cardiovascular and Stroke Nursing; Council on Cardiovascular Radiology and Intervention; Council on Hypertension; and Stroke Council. Assessing and Addressing Cardiovascular Health in People Who Are Transgender and Gender Diverse: A Scientific Statement From the American Heart Association. Circulation. 2021 Jul 8:CIR0000000000001003. doi: 10.1161/CIR.0000000000001003. Epub ahead of print.
PMID: 34235936

Luehrs RE, Moreau KL, Pierce GL, Wamboldt F, Aloia M, Weinberger HD, Make B, Bowler RP, Crapo JD, Meschede K, Kozora E, Moser DJ, Hoth KF. Cognitive Performance is Lower Among Individuals with Overlap Syndrome than with COPD or Obstructive Sleep Apnea Alone: Role of Carotid Artery Stiffness. J Appl Physiol (1985). 2021 May 13. doi: 10.1152/japplphysiol.00477.2020. Epub ahead of print.
PMID: 33982592

Nokoff NJ, Scarbro SL, Moreau KL, Zeitler P, Nadeau KJ, Reirden D, Juarez-Colunga E, Kelsey MM. Body Composition and Markers of Cardiometabolic Health in Transgender Youth on Gonadotropin-Releasing Hormone Agonists. Transgend Health. 2021 Apr 16;6(2):111-119. doi: 10.1089/trgh.2020.0029. PMCID: PMC8080916.
PMID: 33937527

Park YM, Jankowski CM, Swanson CM, Hildreth KL, Kohrt WM, Moreau KL. Bone Mineral Density in Different Menopause Stages is Associated with Follicle Stimulating Hormone Levels in Healthy Women. Int J Environ Res Public Health. 2021 Jan 29;18(3):1200. doi: 10.3390/ijerph18031200.
PMID: 33572819

Grants & Funding

The following research categories have been used to summarize Dr. Moreau's grants/funding (the number in parenthesis is the times that research category has appeared):

• Clinical Research (6)
• Aging (5)
• Cardiovascular (5)
• Prevention (4)

Current Grants

NightWare Therapeutic Platform for improving Cardiovascular Health inAdults With Nightmares Associated with PTSD

Grant number: 1R21AG075544
Funding amount: $233,250.00
Start/End date: 2/1/2022 - 1/31/2023
Funder: National Institute on Aging
NIH website: https://reporter.nih.gov/project-details/10351054

Public Health Relevance Statement
Sleep disturbances due to nightmares is a hallmark symptom of post-traumatic stress disorder (PTSD) and is associated with biomarkers of vascular aging, autonomic dysfunction and increased risk for cardiovascular disease (CVD). We are proposing a pilot clinical trial to assess the effectiveness of the NightWare digital therapeutic intervention (vibration delivered via Apple Watch) vs sham (no vibration) for treating nightmares associated sleep disturbances and cardiovascular health in adults with PTSD-related nightmares.

Cardiovascular Consequences of Hypogonadism in Men

Grant number: R01AG049762
Funding amount: $3,269,267.00
Start/End date: 9/1/2018 - 6/30/2023
Funder: National Institute on Aging
NIH website: https://reporter.nih.gov/project-details/9849152